Jung Im LEE, You Ah KIM, Jinhyeok LEE, Chang-Suk KONG, Haejin KIM, Youngwan SEO
언어
영어(ENG)
URL
https://www.earticle.net/Article/A105208
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원문정보
초록
영어
We have tested inhibition effects of crude extracts of the Arctic terrestrial plant Cerastium sp. on cell proliferation of HT 1080, HT-29, AGS and MCF-7 human cancer cells by the MTT method at 200, 100, 50, 10 and 1 μg/mL concentrations. The plant was extracted for two days with dichloromethane (CH2Cl2) and methanol (MeOH), respectively and then its crude extracts were combined. The inhibitory effects of crude extract increased as a dose dependent manner and showed potential cytotoxic effect in all human cancer cell lines tested, with IC50 0.18 mg/mL on MCF-7 cells, IC50 0.16 mg/mL on AGS cells, IC50 0.10 mg/mL on HT1080 cells, and IC50 0.09 mg/mL on HT-29 cells. The highest inhibition effects of the crude extracts were observed in HT-29 human colon cancer cell line. These results suggest that we can isolate active compounds from Cerastium sp. to show much more strong anticancer activity.
키워드
Cerastium sp.anticancer activityMTT
저자
Jung Im LEE [ Division of Marine Environment & Bioscience, Korea Maritime University ]
You Ah KIM [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Chang-Suk KONG [ Marine Bioprocess Research Center, Pukyong National University ]
Jinhyeok LEE [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Haejin KIM [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Youngwan SEO [ Division of Marine Environment & Bioscience, Korea Maritime University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동