Earticle

초록

영어

Proteomics related toxicology has provided innovative approaches to novel biomarkers screening, toxic materials screening, risk assessments, and predictive toxicology. The application of proteomic analysis in the field of aquatic toxicology has recently started to increase, but until now, little attention has been given to the integrated analysis of molecular responses and higher-level effects within the same study. In this study, protein expression profiles provided significant insights into the toxicity mechanisms for the Daphnia magna, post exposure of heavy metals. We performed proteomic analysis of Daphnia magna in response to Sodium arsenite [As(III)], Sodium arsenate [As(V)], Cadmium nitrate [Cd], As(III)+As(V), As(III)+Cd and As(V)+Cd as a heavy metal, by using two-dimensional gel electrophoresis (2-DE) and found that protein profiles from Daphnia magna were shown different expression patterns for the each heavy metals. In addition, Daphnia magna exposed to the mixture of heavy metals showed different expression patterns. Daphnia magna protein expression profile patterns of binary metal mixtures are not the simple sum of their individual compounds fingerprint.

키워드

저자

• Eun-Suk LIM [ Graduate School of Semiconductor and Chemicl Engineering, Chonbuk National University, Jeonju, Republic of Korea. ]
• Thai Hoang LE [ Graduate School of Semiconductor and Chemicl Engineering, Chonbuk National University, Jeonju, Republic of Korea. ]
• Yang-Hoon KIM [ 1School of Life Science, Chungbuk National University, Cheongju, Republic of Korea. ]
• Jiho MIN [ Graduate School of Semiconductor and Chemicl Engineering, Chonbuk National University, Jeonju, Republic of Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576