Among many biodegradable polymers, poly(lactic acid) (PLA) has been used most widely for a wide variety of pharmaceutical and biomedical applications such as scaffolds for tissue engineering and carriers for controlled drug release because of its proven biocompatibility and favorable regulatory status. However, the high hydrophobicity of PLA results in some problems in particulate formulation of drugs such as too slow drug release and unfriendly environment to hydrophilic drugs. Poly(ethylene glycol) (PEG) is widely used to cloak particles and obtain stealthy properties. PEG is water-soluble, nonionic, nonantigenic and non-immunogenic. In this study, methoxy poly(ethylene glycol)-b-poly(L-lactic acid) (MPEG-PLLA) diblock copolymer was synthesized via a ring-opening polymerization, and then MPEG-PLLA microparticles were prepared by aerosol solvent extraction system (ASES) using supercritical carbon dioxide as antisolvent. The effects of temperature, pressure, initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated.
키워드
Supercritical Carbon DioxideASESMPEG-PLLA
저자
In-Il JUNG [ Dept. of Chemical Engineering, Yonsei University, Seoul, 120-749. ]
Seungjoo HAAM [ Dept. of Chemical Engineering, Yonsei University, Seoul, 120-749. ]
Ji-Eun LEE [ Dept. of Chemical Engineering, The University of Suwon ]
Gio-Bin LIM [ Dept. of Chemical Engineering, The University of Suwon ]
Jong-Hoon RYU [ Dept. of Chemical Engineering, The University of Suwon ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
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