Jeong Sook Noh, Yun Ju Cho, Boh Kyung Kim, Kun Young Park, Eun Ju Cho
언어
영어(ENG)
URL
https://www.earticle.net/Article/A103096
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원문정보
초록
영어
This study examined the antioxidative activity of delphinidin, a kind of anthocyanidin from eggplant. Cellularprotective potential from oxidative damage by nitric oxide (NO), superoxide anion (O2−), and peroxynitrite (ONOO−) usingepithelial cell line LLC-PK1 cell as well as in vitro radical scavenging effects were investigated. Delphinidin showed strong invitro radical scavenging effects against NO, O2−, and hydroxyl radical (·OH) in dose-dependent manners. In addition,delphinidin increased cell viability in LLC-PK1 cells in a concentration-dependent manner when viability was reduced byONOO−-induced oxidative damage. To elucidate the protective mechanisms of delphinidin from ONOO−, sodiumnitroprusside (SNP), and pyrogallol were also employed to generate NO and O2−, respectively. The treatment of delphinidinrecovered reductions in cell viability caused by SNP and pyrogallol, indicating that delphinidin can attenuate oxidative stressinduced by NO and O2−. The present study suggests that delphinidin is a promising antioxidative agent.
목차
Abstract Introduction Materials and Methods Results and Discussion References
Jeong Sook Noh [ Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Korea ]
Yun Ju Cho [ Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Korea ]
Boh Kyung Kim [ Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Korea ]
Kun Young Park [ Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Korea ]
Eun Ju Cho [ Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Korea ]
Corresponding author