Earticle

초록

영어

The aim of this study was to elucidate the anti-inflammatory activity of safflower (Carthamus tinctorius L.)ethanolic extract fractions (CFEFs). Butanol fraction had the strongest antioxidant activity, and all CFEFs, except forchloroform fraction, partly inhibited lipopolysaccharide (LPS)-induced nitrite production in RAW 264.7 cells. In the cell-freesystem, hexane and butanol fractions chemically quenched nitric oxide (NO). In addition, the iNOS mRNA transcription wassuppressed by ethanol extract and hexane fraction in LPS-stimulated RAW 264.7 cells. Taken together, the inhibitory effect ofCFEFs on NO production from LPS-stimulated RAW 264.7 cells, might be due to both the chemical NO quenching activityand the suppression of iNOS mRNA transcription partially. The synthesis of prostaglandin E2 (PGE2) was potently inhibitedby ethanol extract to below basal label, and the transcription of cyclooxygenase-2 (COX-2), an enzyme involving in PGE2synthesis, was partially suppressed by ethanol extract and hexane fraction. Based on these results, CFEFs may be useful as analternative medicine for the relief and retardation of immunological inflammatory responses through the reduction ofinflammatory mediators, including NO and PGE2 production.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자

• Je-Hyuk Lee [ Plant Resources Research Institute, Duksung Women’s University, Seoul 132-714, Korea ]
• Choon Sik Jeong [ College of Pharmacy, Duksung Women’s University, Seoul 132-714, Korea ]
• Gun-Hee Kim [ Plant Resources Research Institute, Duksung Women’s University, Seoul 132-714, Korea; Department of Food and Nutrition, Duksung Women’s University, Seoul 132-714, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664