Earticle

초록

영어

Three traditional Chinese medicines, Agrimonia pilosa Ledeb, Grifola umbellata (pers.) Pilat, and Gambogia, arecombined to form a compound extract, AGC. In this study, the in vitro and in vivo inhibitory effects of AGC on human gastriccarcinoma MGC-803 cells were demonstrated, and the molecular mechanisms underlying these effects are investigated. Ourresults indicate that AGC inhibited MGC-803 cell growth in a dose-dependent manner as measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, with an IC50 of about 6.045±0.69µg/mL. In vivo, AGCinhibited growth of human gastric carcinoma in xenograft tumors in nude mice, and the inhibitory rate reached 55.2% at 300mg/kg. The pro-apoptotic activity of AGC was attributed to its ability to decrease the expression of Bcl-2 and Pro-caspase3and increase the expression of Bax. These results demonstrate that AGC can effectively induce programmed cell death andmay be a promising anti-tumor drug in human gastric carcinoma.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자

• Li Zhao [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ]
• Xiao-Nan Zhang [ Department of Pharmacology, the Fourth Military Medical University, Xi’an 710032, PR China ]
• Hong-Yan Gu [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ]
• Jia Wang [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ]
• Lei Tao [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ]
• Rong Mu [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ]
• Qing-Long Guo [ Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, PR China ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664