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Glycerides from the Aerial Parts of Garland (Chrysanthemum coronarium L.) and Their Inhibitory Effects on ACAT, DGAT, FPTase, and β-Secretase

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 18 Number 1 (2009.02)바로가기
  • 페이지
    pp.95-102
  • 저자
    Myoung-Chong Song, Hye-Joung Yang, Jin-Gyeong Cho, In-Sik Chung, Nam-In Baek, Byoung-Mog Kwon, Dae-Keun Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A103084

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원문정보

초록

영어
The aerial parts of garland (Chrysanthemum coronarium L.) were extracted in 80% aqueous methanol (MeOH)and the concentrated extract was then partitioned using ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively.EtOAc and n-BuOH fractions resulted in 4 glycerides with the application of octadecyl silica gel and silica gel columnchromatography. The chemical structures of the glycerides were determined using several spectroscopic methods, includingnuclear magnetic resonance (NMR) and mass spectrometry (MS) as (2S)-1-O-palmitoyl-sn-glycerol (1), (2S)-1-O-oleoyl-2-O-oleoyl-3-O-β-D-galactopyranosyl-sn-glycerol (2), (2S)-1-O-palmitoyl-2-O-linoleoyl-3-O-phosphorouscholine-sn-glycerol (3),and (2S)-1-O-linolenoyl-2-O-palmitoyl-3-O-[α-D-galactopyrasyl-(1→6)-β-D-galactopyranosyl]-sn-glycerol (4). The free fattyacids of these glycerides were determined with gas chromatography (GC)-MS analysis following alkaline hydrolysis andmethylation. These glycerides demonstrated an inhibitory effect on acyl-CoA: cholesterol acyltransferase (ACAT, compound1: 45.6±0.2% at 100µg/mL), diacylglycerol acyltransferase (DGAT, compound 1: 59.1±0.1% at 25µg/mL), farnesyl proteintransferase (FPTase, compound 2: 98.0±0.1%; compound 3: 55.2±0.1% at 100µg/mL), and β-secretase (IC50, compound 4:2.6µg/mL) activity. This paper is the first report on the isolation of these glycerides from garland and their inhibitory activityon ACAT, DGAT, FPTase, and β-secretase.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

Chrysanthemum coronarium glyceride acyl-coenzyme A: cholesterol transferase (ACAT) acyl-coenzyme A:diglycerol acyltransferase (DGAT) farnesyl protein transferase (FPTase) β-secretase

저자

  • Myoung-Chong Song [ Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, Gyeonggi 446-701, Korea ]
  • Hye-Joung Yang [ Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, Gyeonggi 446-701, Korea ]
  • Jin-Gyeong Cho [ Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, Gyeonggi 446-701, Korea ]
  • In-Sik Chung [ Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, Gyeonggi 446-701, Korea ]
  • Byoung-Mog Kwon [ Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600, Korea ]
  • Dae-Keun Kim [ Department of Pharmacy, Woosuk University, Jeonju, Jeonbuk 565-701, Korea ]
  • Nam-In Baek [ Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University, Suwon, Gyeonggi 446-701, Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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