Earticle

초록

영어

Cathepsin S is a cysteine protease that affects extracellular matrix remodeling. Recently, several studies havereported that cathepsin S is involved in obesity. Both mouse and human adipose cells produce this enzyme in the early phaseof adipocyte differentiation, where it degrades fibronectin. Cathepsin S gene expression is elevated in the adipose tissue ofobese mice as compared to that of lean mice. Paecilomyces tenuipes water extracts (PTW) are shown to have an inhibitoryeffect on cathepsin S activity. In this study, Z-Val-Val-Arg-MCA was used as a cathepsin S-specific substrate in order toexamine inhibitory effect of PTW. Supplementing 3T3-L1 cell media with PTW clearly reduced lipid droplet accumulationand cathepsin S-induced adipogenesis. Furthermore, PTW decreased weight gain, subcutaneous adipose tissue growth, thelevel of serum triglyceride, and total cholesterol in mice fed a high-fat diet. These data suggest that PTW work against adiposecathepsin S and presumably contribute to anti-obese activities.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자

• Kil-Sun Myoung [ R&D Center, Korea Yakult Co., Ltd., Yongin, Gyeonggi, Korea ] Corresponding author
• Jung-Hee Lee [ R&D Center, Korea Yakult Co., Ltd., Yongin, Gyeonggi, Korea ]
• Kwang-Sei Lim [ R&D Center, Korea Yakult Co., Ltd., Yongin, Gyeonggi, Korea ]
• Chul-Sung Huh [ R&D Center, Korea Yakult Co., Ltd., Yongin, Gyeonggi, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664