Earticle

초록

영어

The antitumor effects of mice fed with cell lysate of Lactobacillus plantarum were studied. The abdominal cancer induced by Sarcoma-180 was markedly inhibited and the expected life span was extended by 60% for the Balb/c mice fed with L. plantarum cell lysate for two weeks. A similar result was obtained for the rat inoculated with Spontaneous Osteosarcoma(SOS). The primary tumor volume of SOS was reduced by 70% for the rats fed with L. plantarum cell lysate (100mg/kg/day) for one week before the inoculation of SOS, while only 42% for the rats fed with the same amount of cell lysate for one week after the inoculation of tumor cell line, SOS. As lung was the metastasis site of SOS, the weight of lung was measured to determine the degree of metastasis inhibition by the L. plantarum cell lysate feeding. The rats fed with cell lysate for one week showed a remarkable inhibition of lung metastasis by 63%(before) and 46%(after), respectively. These results indicate that the feeding of L. plantarum cell lysate to mouse or rat can induce a strong stimulation of mucosal or systemic immune system and these effects results in an efficient antitumor activity.

목차

서론
 재료 및 방법
  복수암물 이용한 항함효과의 측정
  허파 전이암을 이용한 항함효과 측정
  대식세포의 Nilnc Oxide(NO) 생성 측정
  장내 분비 Immunogiobulin A(slgA) 변화량 측정
 결과 및 고찰
  복수암 저지 효과
  일차적 암 발생부위와 허파전이암의 측정
  일차암 및 폐 전이암 저지 효과
  담암쥐의 면역활성 효과
 요약
 감사의 글
 참고문헌

키워드

저자

• 신경섭 [ Kyungsup Shin | 건국대학교 미생물공학과 ]
• 채옥화 [ Okwha Chae | 건국대학교 미생물공학과 ]
• 박인철 [ Inchul Park | 원자력병원 세포생물학실 ]
• 홍석일 [ Seokil Hong | 원자력병원 세포생물학실 ]
• 최태부 [ Taeboo Choe | 건국대학교 미생물공학과 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  KSBB Journal

• 간기

  격월간

• pISSN

  1225-7117

• 수록기간

  2009~2013

• 십진분류

  KDC 476 DDC 576