Earticle

초록

영어

To investigate the possible association between −2510A/G promoter polymorphism (rs1024611) ofchemokine (C-C motif) ligand 2 (CCL2) gene and rheumatoid arthritis in Korean population. DNAs were obtained from192 Korean rheumatoid arthritis patients and 270 healthy controls. CCL2 genomic variants (−2510A/G polymorphism)were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The −2510A/Gpromoter polymorphism was not associated with rheumatoid arthritis [genotype frequency (P=0.710); allele frequency(P=0.813, OR=1.033, 95% CI=0.79−1.36)]. The −2510A/G promoter polymorphism is not associated withrheumatoid arthritis, suggesting −2510A/G promoter polymorphism is not a susceptibility factor in the development ofrheumatoid arthritis in Korean population. However, G allele is a major allele in Asian including Korean, whereas amajor allele in Caucasian and European is A. The ethnic difference is present in −2510A/G promoter polymorphism.

목차

ABSTRACT
 1. Introduction
 2. Materials and methods
  2.1 Study population
  2.2 Extraction of DNA from blood
  2.3 Screening of SNPs in area of CCL2 gene
  2.4 Polymerase chain reaction (PCR) andrestriction fragment length polymorphism (RFLP)
  2.5 Statistics
 3. Results and discussion
 References

키워드

저자

• Ji Young Yoo [ Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea ]
• Yong Ho Kim [ Department of Surgery, School of Medicine, Kyung Hee University, Seoul 130-701, Korea ]
• Bum Shik Kim [ Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyung Hee University, Seoul 130-701, Korea ]
• Joo Ho Chung [ Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea ] 교신저자

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  응용미약자기에너지학회지 [Journal of Applied Micromagnetic Energy]

• 간기

  반년간

• pISSN

  1738-4427

• 수록기간

  2003~2018

• 십진분류

  KDC 428 DDC 538