Yoon Jung Kim, Jae Yang Song, Soon-Kwang Hong, Colin P. Smith, Yong Keun Chang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100303
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원문정보
초록
영어
Effects of pH shock on the secretion system of S. coelicolor A3(2) have been investigated at a transcriptional level by using DNA microarrays. Actinorhodin secretion was observed to be highly enhanced when an acidic pH-shock was applied to surface grown cultures of S. coelicolor A3(2). In this culture, a gene of actVA-orf1 coding a putative efflux pump or transporter protein for actinorhodin was strongly upregulated. A major number of efflux pumps for other metabolites, and a major number of secretion proteins for protein secretion were also observed to be upregulated with pH shock. The secretion of actinorhodin was observed to be remarkably enhanced in liquid culture also.
Yoon Jung Kim [ Dept. of Chemical and Biomolecular Engineering (The Brain Korea 21 Program), Korea Advanced Institute of Science and Technology ]
Jae Yang Song [ Dept. of Chemical and Biomolecular Engineering (The Brain Korea 21 Program), Korea Advanced Institute of Science and Technology, Functional Genomics Laboratory, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom ]
Soon-Kwang Hong [ Division of Bioscience and Bioinformatics, Myung-Ji University ]
Colin P. Smith [ Functional Genomics Laboratory, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom ]
Yong Keun Chang [ Dept. of Chemical and Biomolecular Engineering (The Brain Korea 21 Program), Korea Advanced Institute of Science and Technology ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동