Earticle

초록

영어

Ntirogen source dependent growth and antibiotics production regulator (NdgR) was initially found from S. peucetius by DNA affinity capture assay method. NdgR was well conserved not only through the completely sequenced Streptomcyes species such as S. coelicolor and S. avermitilis, but also through many other bacteria such as Mycobacteria and Corynebacteria. Furthermore, it is quite different from known IclR-type regulators, which are known to be involved in glycerol operon, acetate production and sporulationspecific cell division and morphogenesis. In S. coelicolor, ndgR deletion mutant showed overall late growth and promoted actinorhodin (ACT) production in minimal media with various amino acids, even where wild type strain could not produce ACT. According to RT-PCR results, it was observed that NdgR affects glutamine/glutamate and proline. Moreover, surprisingly, it controls S. coelicolor quorum sensing system such as scbR/scbA by binding to its promoter region and autoregulate itself.

저자

• Yung-Hun YANG [ School of Chemical and biological Engineering, Seoul National University ]
• Eun-Jung KIM [ School of Chemical and biological Engineering, Seoul National University ]
• Eunjung SONG [ School of Chemical and biological Engineering, Seoul National University ]
• Kwangwon LEE [ School of Chemical and biological Engineering, Seoul National University ]
• Woo-Seung KIM [ School of Chemical and biological Engineering, Seoul National University ]
• Kwangkyung LIOU [ Institute of Biomolecule Reconstruction Lab, Sunmoon University ]
• Hei-Chan LEE [ Institute of Biomolecule Reconstruction Lab, Sunmoon University ]
• Jae-Kyung SOHNG [ Institute of Biomolecule Reconstruction Lab, Sunmoon University ]
• Byung-Gee KIM [ School of Chemical and biological Engineering, Seoul National University ]

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간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576