Young-Sook Cho, Jung-Ae Kim, Jin-Sook Park, Se-Kwon Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100291
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Reactive oxygen species (ROS) are constantly generated in aerobic organisms during normal metabolism in response to both internal and external stimuli. Imbalances in the production and removal of ROS have been hypothesized to play a causative role in numerous disease such as cancer, ischemia/reperfusion injury and degenerative diseases such as photoaging, atherosclerosis, arthritis, and neurodegeneration. A feature often associated with these diseases is a malfunctioning of the connective tissue remodeling process due to increased activity of extracellular matrix metallo proteinases (MMPs). Algae extracts have been studied as potential natural antioxidants in recent years. Coralline red alga, Amphiroa dilatata is distributed widely coastal area of east asia. In the present study, the free radical scavenging potency and inhibitory effects methanolic extract Amphiroa dilatata(AD) on ROS production and MMP-2 and 9 activities were investigated It's scavenging activity of ROS such as 1,1-diphenyl-2-picrylhydrazyl(DPPH), superoxide and alkyl radical was determined using electron spin resonance(ESR) spectroscopy. The levels of intracellular ROS was measured using 2,7- chlorofluorescindiacetate. Their levels significantly decreased in the presence AD extracts, and the DPPH radical scavenging effects were higher than superoxide and alkyl radicals. Furthermore, MMP-2 and -9 expression levels were significantly decreased in a dose dependent manner by treatment of AD extracts. Therefore, these results suggest that AD extract could have a therapeutic potential for prevention and treatment of several diseases such as tumor metastasis, inflammation and neurodegeneration.
저자
Young-Sook Cho [ Department of Chemistry, Pukyong National University ]
Jung-Ae Kim [ Department of Chemistry, Pukyong National University ]
Jin-Sook Park [ Department of Chemistry, Pukyong National University ]
Se-Kwon Kim [ Department of Chemistry, Pukyong National University, Marine Bioprocess Research Center, Pukyong National University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동