Hyo-Sung Kim, Cheol Hee Kim, Min Chul Kwon, Syed Abdul Qadir, Sang Hee Lee, Hyeon Yong Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100208
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원문정보
초록
영어
The purpose of this study was to investigate the effect of low molecular peptides of Asterias amurensis on skin immune activation. This peptides were isolated form A. amurensis by enzymetic method with ultrasonication. The inhibitory effect of the peptides on hyaluronidase and PGE2 in UV-irradiated human dermal fibroblast were also performed. Among the peptides, F4(38 kDa) showed the strongest PGE2 and Hyaluronidase inhibitory activities1). The F4(38 kDa) peptides reduced nitric oxide production about 250% by adding 1.0 ㎎/㎖ compared with LPS(lipopolysaccharides). The cytotoxicity of peptides at 1.0 ㎎ /㎖ was below 15%. At 0.2 ㎎/㎖ of the F4(38 kDa) peptides, PGE2 expression2) was inhibited significantly compared with control. These results imply that the F4(38 kDa) peptides could be used as a new immuno-modulating agent for the skin.
저자
Hyo-Sung Kim [ School of Biotechnology and Bioengineering, Kangwon National University ]
Cheol Hee Kim [ School of Biotechnology and Bioengineering, Kangwon National University ]
Min Chul Kwon [ School of Biotechnology and Bioengineering, Kangwon National University ]
Syed Abdul Qadir [ School of Biotechnology and Bioengineering, Kangwon National University ]
Sang Hee Lee [ School of Biotechnology and Bioengineering, Kangwon National University ]
Hyeon Yong Lee [ School of Biotechnology and Bioengineering, Kangwon National University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동