Minchul Kwon, Cheol Hee Kim, Hyo Sung Kim, Syed Abdul Qadir, Sang Hee Lee, Hyeon Yong Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100184
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원문정보
초록
영어
This study was carried out to investigate the anti-wrinkle effects of the peptides derived from collagens isolated from Asterias amurensis collected in East Sea. Molecular weight of peptides were between 10 kDa - 50 kDa through sephadex G-75 gel1). The cytotoxicity against CCD-986sk cell and HEL-299 cell were measured using the MTT assay. All of the fractions (F1 : Fraction No. 4-13, 116 kDa, F2 : Fraction No.25-30, 100 kDa, F3 : Fraction No.45-55, 58 kDa, F4 : Fraction No.59-63, 43 kDa, F5 : Fraction No.79-90, 24 kDa) in adding 1.0 ㎎/㎖ showed that cytotoxicity below 25%. The peptides derived from A. amurensis did not show any adverse effects on human skin cell by enzymetic method. We studied in in-vitro cultures of human normal fibroblast. In the presence of F1 at 1.0 ㎎/㎖, UVA-induced matrix metalloproteinase-1(MMP-1) expression2) was reduced to 34.8%. It seems that about 20 kDa peptides have superior anti-wrinkle effect.
저자
Minchul Kwon [ College of Bioscience & Biotechnology, Kangwon National University ]
Cheol Hee Kim [ College of Bioscience & Biotechnology, Kangwon National University ]
Hyo Sung Kim [ College of Bioscience & Biotechnology, Kangwon National University ]
Syed Abdul Qadir [ College of Bioscience & Biotechnology, Kangwon National University ]
Sang Hee Lee [ College of Bioscience & Biotechnology, Kangwon National University ]
Hyeon Yong Lee [ College of Bioscience & Biotechnology, Kangwon National University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동