In living organisms, reactive oxygen species arise from endogenous oxidative metabolism or exogenous stresses, such as UV light, ionizing radiation, and some types of redox agents, causing oxidative damage to proteins, nucleic acids, and unsaturated fatty acids in lipids. Reactive oxygen species and other free radical emissions by cells and tissue are often taken as an indicator and a cause of aging in vitro and in vivo. In the case of MSC however, ROS was also shown to be involved in signaling, down-regulating proliferation and stimulating apoptosis or differentiation processes. Mesenchymal stem cells (MSC) are of great therapeutic potential because of their ability to self-renew and differentiate into multiple tissues. A hot new topic in medical treatment is the use of MSC in therapy. So we confirmed the changes of hMSC apoptosis caused by ROS using various tools for apoptosis assay. And we performed proteome profiling to find apoptosis associated regulators.
저자
Ji-Soo Kim [ School of Life Sciences and Biotechnology, Korea University ]
Mi-Ryung Kim [ School of Life Sciences and Biotechnology, Korea University ]
Chan-Wha Kim [ School of Life Sciences and Biotechnology, Korea University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동