The development of magnetic nanoparticles for specific targeting of cell therapeutics has been the main issue in biomedical research. A common problem in therapeutic application of stem cells is that the cells rapidly disappear in circulatory system after the injection of the cells. In this study, we conducted an experimental study in microfluidic system with magnetic nanoparticles, isolated from the Magnetospillum sp. AMB-1. Magnetic nanoparticles were delivered to the stem cells (Endothelial Progenitor Cell, EPC) ranged from 0 to 20 µg per 104 cells and their behaviors were controlled by a NdBFe magnet. A blood vessel was modeled by a single microchannel and the flow rate was uniformly controlled by a syringe pump. We investigated the cell behaviors according to the flow rate and the amount of magnetic particles taken up into the cells. The magnetic nanoparticles-introduced cells at a concentration of 50 µg per 104 cells under 0.4 T were fixed at a flow rate of 1.6 µl min-1. This microfluidic system would be a useful tool for better understanding of the behavior of magnetic nanoparticle-introduced cells in the human circulatory system for clinical applications.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동