Ju-yeop Lee, Min-Chul Kang, Bong-Seok Kim, Kwang-Hyo Ko, Jong-Heon Han, Jung-A Lee, Haeng-Bum Kim, Seung-Hyun An, Se-Jae Kim, Gi-Ok Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100080
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Melanogenesis is a physiological process resulting in the synthesis of melanin pigments, which play a crucial protective role against skin photocarcinogenesis. EtOH extract and various fractions from M. micromalus were analysed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) radicals, superoxide radical, Xanthine oxidase, respectively. And it’s results, EtAOc fraction inhibited the DPPH (IC50 : 1.2g/ml), NO radicals (IC50 : 584.9g/ml), superoxide radical (IC50 : 0.6g/ml), Xanthine oxidase (IC50 : 4.9g/ml) on low concentration. The study was designed to investigate the inhibitory effect of extract from M. micromalus on melanogenesis in Melan-a cells. We also estimated total melanin content as a final product and activity of tyrosinase, a key enzyme, on melanogenesis in Melan-a cells. The melanin content and tyrosinase activity were decreased in extract-treated cells in a dose dependent manner compared to control group. EtAOc fractions of M. micromalus significantly inhibited cell tyrosinase activity and melanin content and this inhibitory action was not due to the cytotoxicity. Taken together, this study suggests that EtAOc fractions of M. micromalus could contribute to the melanogenesis inhibition.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동