Earticle

초록

영어

There is a growing interest in finding skin depigmenting agents from natural sources in the cosmeceutical and pharmaceutical markets. In this study, methanol extracts of 57 traditional medicinal plants growing in Vietnam and 45 plants growing in China were evaluated. Cell-based and non-cell-based assays were performed to measure (i) melanin contents, (ii) cell viability, (iii) antioxidant activity, and (iv) tyrosinase inhibitory activity. The screening results revealed that 14 Vietnamese plants and eight Chinese plants had high potentials as skin whitening agents. For further isolated, S1 sample was chosen. Its methanol extract exhibited a 32.91% and 64.93% inhibition of melanin synthesis on B16F10 cells and Melan-a cell without cytotoxicity at a concentration of 200µg/ml. Moreover, this extract inhibited mushroom tyrosinase as well as intracellular tyrosinase and has high antioxidant activity. To elucidate the mechanism of S1–induced depigmenting activity, the protein level of tyrosinase was also determined by Western blotting. These results suggested that S1 sample could be a high potential candidate as a skin depigmenting agent in the cosmeceutic and pharmaceutical industries.

키워드

저자

• Uyen Do Phuong Lam [ Department of Biological Engineering, Inha University ]
• Dung Hoang Nguyen [ Department of Biological Engineering, Inha University ]
• Jung-Hyun Kim [ Department of Biological Engineering, Inha University ]
• Hyang-Bok Lee [ Department of Biological Engineering, Inha University ]
• Hae-Jong Kim [ Department of Biological Engineering, Inha University ]
• Jeong-Hyun Shin [ Department of Dermatology, College of Medicine, Inha University ]
• Eun-Ki Kim [ Department of Biological Engineering, Inha University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576