Dung Hoang Nguyen, Hyang-Bok Lee, Uyen Do Phuong Lam, Jung-Hyun Kim, Jeong-Hyun Shin, Eun-Ki Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100068
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Because of the visible nature of dermatologic diseases such as melasma, lentigines, they have a considerable psychological effect on affected patients. To treat these diseases, a number of skin whitening compounds have been screened for their effectiveness in reducing melanogenesis but none are satisfactory. To developing new and safe skin whitening agents from natural sources, Chinese plants have been evaluated. From screening results, Lasa B29 inhibited 43.7% melanin synthesis of murine B16F10 melanoma cells and exhibited low cytotoxicity (8.1%) at a concentration of 100 ug/ml. To find the mechanism of melanin inhibition, inhibitory activity on tyrosinase, the key enzyme of melanogenesis, was further evaluated. The results showed inhibitory effects on the activity of intracellular tyrosinase (34.7% at 100 ug/ml) but not the mushroom tyrosinase. To isolate an effective compound, silica open column chromatography, and preparative high performance liquid chromatography were used.
키워드
Melanogenesisskin whiteningdermatologic diseases
저자
Dung Hoang Nguyen [ Department of Biological Engineering, Inha University ]
Hyang-Bok Lee [ Department of Biological Engineering, Inha University ]
Uyen Do Phuong Lam [ Department of Biological Engineering, Inha University ]
Jung-Hyun Kim [ Department of Biological Engineering, Inha University ]
Jeong-Hyun Shin [ Department of Dermatology, Inha Univesity Hospital ]
Eun-Ki Kim [ Department of Biological Engineering, Inha University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동