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Cosmetic application for Bis-ethylhexyloxyphenolmethoxyphenyl triazine(BEMT) loaded Solid Lipid Nanoparticle(SLN) ; in vitro release and in vivo skin penetration
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2007 추계학술대회 및 국제심포지엄 (2007.10)바로가기
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- 페이지
- pp.13-14
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A100064
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Sun protecting substances are capable of protecting humans from harmful effects solar radiation such as aging and skin cancer (1, 2). Bisethylhexyloxyphenolmethoxyphenyltrizine(BEMT) is one of the most widely used oil-soluble UVA+UVB absorber in sunscreen cosmetic product. Stratum corneum is the major barrier in percutaneous absorption process (3, 4). The purpose of this study is to confirm the skin delivery property and synergistic UV-blocking effect of solid lipid nano-particles containing the BEMT with a sun screen agent. The study of skin permeability is important, and performed by various methods. In this study, target active ingredient is BEMT. I compared in vitro release and penetration of this active ingredient in O/W emulsion and SLN
formulation. According to Wissing, The release rate of oxybenzone is decreased when using SLN formulations compared emulsions (5). As a result, in vitro penetration and release of BEMT is generally higher O/W emulsion than the SLN formulation. After having a 24 hours, cumulative transdermal absorption amount of BEMT is higher emulsion(16.04㎍/㎠) than SLN formulation(4.21㎍/ ㎠). The other hand, in vivo study, penetration of BEMT into the skin was investigated by the stripping method. It was shown that the rate of release could be decreased by 80% in the SLN formulation. SLN matrix sustained release carrier system, therefore sunscreen agent remain longer on the skin. And the occlusive effect of SLN was physical sunscreen with increased synergistic UV-blocking effect (6). In vitro UV protection result, the sun protection factor
(SPF) could be increased by 100% in the SLN formulation. Therefore, BEMT-SLN led synergistic UV-blocking behavior. The BEMT residual content gradually decreased to 80.9% over 12 hours the result of UV radiation, but the residual content of BEMT with an encapsulated solid lipid decreased to only 92.3%. Also the BEMT-SLN led to improve of photochemical stability effect on
ultra violet. Ultimately it appeared that Solid lipid nanoparticle was the most effective to
adopt BEMT and may be used for a useful drug delivery system in the sun care product.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
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