Jin-Ho Lee, Sang-Uk Kim, Cheol-Heon Yea, Byung-Keun Oh, Jeong-Woo Choi
언어
영어(ENG)
URL
https://www.earticle.net/Article/A100008
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원문정보
초록
영어
In the present research, a novel ultra-sensitive detection method of β-amyloid 1-40 was investigated by scanning tunneling microscopy (STM). It is known that, β-amyloid 1-40 is a most challenging marker for the early diagnosis of alzheimer disease. So, to achieve this, an ultra-sensitive detection system for β-amyloid 1-40 is required. In this study, novel ultra-sensitive of β-amyloid 1-40 was developed and STM was performed for it's investigation. In STM, the frequency of current peaks was measured in accordance with the surface density of the dispersed Au nanoparticle-antibody complex on the gold surface. Which was represented as periodogram with it's logarithmic regression curve, and the change of the power spectrum was observed in accordance with the concentration of β-amyloid 1-40 molecule. the lowest detection limit of the assay system for β-amyloid 1-40 was found as 1fg/ml.
저자
Jin-Ho Lee [ Department of Chemical & Biomolecular Engineering, Sogang University ]
Sang-Uk Kim [ Interdisciplinary Program of Integrated Biotechnology, Sogang University ]
Cheol-Heon Yea [ Department of Chemical & Biomolecular Engineering, Sogang University ]
Byung-Keun Oh [ Department of Chemical & Biomolecular Engineering, Sogang University, Interdisciplinary Program of Integrated Biotechnology, Sogang University ]
Jeong-Woo Choi [ Department of Chemical & Biomolecular Engineering, Sogang University, Interdisciplinary Program of Integrated Biotechnology, Sogang University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동