Earticle

초록

영어

Recently many scientists have been researching into alcoholic liver damage or liver disease, because of alcohol consumption causing severe social (or public) problems, such as addiction by alcohol, alcohol abuse and liver disease. Alcohol consumption is known to cause severe acute liver damage resulting in hepatic fibrosis and liver cirrhosis, when chronically consumed. The mechanism by which alcohol induces its damaging effects on the liver are poorly understood. This study discusses the current definition of alcoholic liver disease and the role of the components involved in innate immune response. In particular, the effect of Kupffer cells, macrophages which are present in liver, on alcohol-induced liver diseases. This review will contribute to understanding the mechanism responsible for alcoholic liver disease and the relation between the innate immune response and the pathogenesis of alcoholic liver disease.

목차

I. 서론
 II. 본론
  A. 알코올 (alcohol)이란 무엇인가?
  B. 알코올성 간질환(alcoholic liver disease, ALD)
  C. 알코올의 대사 (metabolism)
  D. 알코올성 간질환의 발병기전(Pathogenesis of alcoholic liver disease)
  E. 알코올에 대한 간의 반응
  F. 자연면역반응 (innate immune response)과 알코올
  G. 간의 대식세포인 Kupffer cell의 기능
  H. 내독소(endotoxin)에 의한Kupffer cell 활성화의 결과
  I. Kupffer cell과 내독소에 의한 세포 내 신호전달 경로
  J. 급성 알코올 독성과 염증세포 내에서의 신호전달과정
 Ⅲ. 논의 및 결론
 참고문헌
 

저자

• 강태진 [ Taejin Kang | 삼육대학교 약학대학 ] 교신저자

참고문헌