Earticle

초록

영어

Bovine rotavirus (BRV) is one of the common gastrointestinal diseases that can occur in calves, causing severe diarrhea. This study was conducted to investigate the effects of oral administration of single-domain antibodies, single variable domain of heavy chain of HCAb (VHH), on the prevention and treatment of rotavirus-induced diarrhea in calves. Thirty calves were divided into five experimental groups (negative control, positive control, group A, group B and group C). Except for the negative control group, the experimental groups were inoculated with BRV on the 4th day after birth. The VHH supplementation groups were fed with a substitute milk containing different concentrations of VHH (1%, 2.5% and 7.5%). Changes in body weight, clinical symptoms, serum antibodies, and virus detection in feces were observed for a total of 10 days in each experimental group. The results showed a higher survival rate in the VHH supplementation groups compared to the positive control group. Clinical symptoms caused by rotavirus were alleviated in the VHH supplementation groups. The detection rate of rotavirus in feces also decreased. Gross findings indicated that the severity of disease in the VHH supplementation groups was milder than that in the positive control group. Therefore, VHH could be proposed as a useful alternative for the prevention and treatment of rotavirus-induced diarrhea in calves.

목차

ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
1. 공시재료
2. 공시동물
3. 사양관리
4. 공격접종
5. 예방 및 치료 효과 지표
6. 통계처리
Ⅲ. 결과
1. 체중
2. 임상증상
Ⅳ. 요약
Ⅴ. 참고문헌

저자

• Song-Yi Yang [ Manager ADBIOTECH IND. CO., LTD., Chuncheon 24398, Korea. Researcher ]
• Yang-Hee Kim [ Researcher, Manager ADBIOTECH IND. CO., LTD., Chuncheon 24398, Korea ]
• Sung-Jin Lee [ Professor, Department of Applied Animal Science, Kangwon National University, Chuncheon 24341, Korea ]
• Jeong-Hee Han [ Professor, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Kore ] Corresponding Author

참고문헌