Earticle

초록

영어

Lyophyllum decastes has been used for culinary purpose. The present study was conducted to evaluate the antioxidant and anti-inflammatory effects from methanol, acetone, and hot water extracts of L. decastes fruiting bodies. The acetone and methanol extracts showed the higher 1,1-diphenyl-2-picryl-hydrazy radical scavenging activities than that of the hot water extract at 0.5–2.0 mg/mL and was comparable to the BHT, the positive control. The ferrous ion chelating effects of the mushroom extracts at 0.5–2.0 mg/mL were significantly higher than that of BHT. The reducing power of acetone extract (2.12) was significantly lower than that of BHT (2.73) at 2.0 mg/ mL. The mushroom extracts also showed inhibitory effects on production of nitric oxide (NO), and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide-induced murine macrophage cells in a concentration dependent manner. In vivo anti-inflammatory experiment on carrageenan-induced hind-paw edema of rat model, the acetone extract of the mushroom significantly suppressed the carrageenan-induced rat hind paw edema of rats in a dose dependently. The results suggest that the fruiting bodies of Lyophyllum decastes are a good natural resource of antioxidant and anti-inflammation.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Mushrooms and extraction
Animals
Assay for the total phenol content
Assay for the total flavonoid content
Evaluation of antioxidant activity
Evaluation of anti-inflammatory activity
RESULTS AND DISCUSSION
Evaluation of phenolic contents
Evaluation of flavonoid contents
Evaluation of Antioxidant Activities
Anti-inflammatory activity of fruiting body extracts of L. decastes
REFERENCES

저자

• Ki Nam Yoon [ Department of Clinical Laboratory Science, Ansan University ]
• Tae Soo Lee [ Division of Life Sciences, Incheon National University ] Corresponding Author

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