Yanbian Korean Autonomous Prefecture is local in China, north Korea and Russia border, and there is special geographic location and complex population component. Therefore, it is an area where drug-related crimes area exchanged. Yanbian area has been taking a series of measures of prevention and control improvement of drug-related crime, and made great achievements. But, a number of measures are lack of some effectively implementary methods. So there are some issues at the phase of prevention and control of drug-related crimes. On this premise, on the basis of understanding the current situation of drug crime prevention and control in Yanbian area, this paper analyzes the existing problems, and through studying and referring to the countermeasures of drug crime prevention and control in Guizhou and Yunnan, Based on the specific problems existing in Yanbian Korean autonomous prefecture, this paper puts forward some specific suggestions, such as the establishment of local legislation, the strengthening of cooperation among the governments, the introduction of modern information technology for unified management, and the improvement of anti-drug publicity and ect.