Earticle

초록

영어

According to Livestock Inspection Standards, the piglets enter the feedlot at approximately 30 kg, and the inspection starts after the preliminary feeding period. The reason for applying the preliminary feeding period is to select inspection piglets with no diseases after the complete growth of the internal organs until 10 weeks of age. Furthermore, the age of 10 week is the time when the muscle fibers grow to their maximum size and the piglets are prepared for fat deposition at the later fattening period. In the study, a genome-wide association study (GWAS) was performed through the mlma command of the genome-wide complex trait analysis (GCTA) program with 703 purebred Landrace population, and the candidate genes associated with the weight of 10 week were searched. The GWAS identified 3 single nucleotide polymorphism (SNP) markers, which have a significant genome-wide suggestive level, on chromosome 6 (DIAS0002615; p value=1.62×10-6, MARC0083933; p value=4.94×10-6, ASGA0028717; p value=5.40×10-6). The 2 genes (Ubiquitin protein ligase E3 component n-recognin 4; UBR4, WD and tetratricopeptide repeats 1; WDTC1) in which these 3 SNP markers are located are positional candidate genes of the weight of 10 week of the purebred Landrace population. 2 candidate genes have been reported to be associated with fattening. Therefore, the positional candidate genes in this study, UBR4 and WDTC1, are expected to be usable as genes for traits associated with the weight of 10 week weight and fattening through additional experimental research with other population.

목차

ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
1. 공시 동물 및 DNA 추출
2. 10주령 체중 형질 측정
3. 데이터 기초분석 및 전장유전체 연관성 분석
Ⅲ. 결과 및 고찰
Ⅳ. 요약
사사
Ⅴ. 참고문헌

저자

• 강호찬 [ Ho-Chan Kang | 경상대학교 농업생명과학대학 축산학과 ]
• 이재봉 [ Jae-Bong Lee | 전북대학교 인수공통전염병연구소 ]
• 유채경 [ Chae-Kung Yoo | 경상대학교 농업생명과학연구원 ]
• 최태정 [ Tae-Jeong Choi | 농촌진흥청 국립축산과학원 양돈과 ]
• 임현태 [ Hyun-Tae Lim | 경상대학교 농업생명과학대학 축산학과, 경상대학교 농업생명과학연구원 ] Corresponding Author

참고문헌