Earticle

초록

영어

In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dosedependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down- regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.

목차

ABSTRACT
 서론
 재료 및 방법
  버섯시료 추출 방법
  세포 배양
  분석방법
  RNA isolation
  역전사 반응(Reverse Transcription-Polymerase Chain Reaction, RT-PCR)
  PCR정량 분석
  통계처리
 결과 및 고찰
  전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 PSA mRNA 발현 억제효과
  전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 혈관신생인자 발현 억제효과
 적요
 감사의 글
 References

저자

• 최영진 [ Young-Jin Choi | 건국대학교 식품생명과학부 ]
• 범미기 [ Meiqi Fan | 건국대학교 식품생명과학부 ]
• 최은주 [ Eun-Ju Choi | 대구가톨릭대학교 체육교육과 ]
• 김은경 [ Eun-kyung Kim | 건국대학교 식품생명과학부 ] Corresponding author

참고문헌