Cordyceps militar is (Clavicipitales) is an edible mushroom which is widely distributed in China, Japan and Korea. Various phytochemical constituents, cordycepin, homocitrully laminoadenosine and sterols have been reported from this source and a wide range of biological activities, including antimicrobial, macrophage activation, anticancer, immune modulatory effects were studied. In a continuing search for bioactive constituents from Korean mushrooms, we performed a phytochemical investigation of the MeOH extract from the fruiting bodies of C. militaris. By repeated column chromatographic separation of the extract, fourteen compounds, were isolated. The identification and structural elucidation of the compound was based on NMR spectral data. anti-aging activities were performed on adriamycin-induced cellular senescence model. Human dermal fibroblasts(HDFs) and human umbilical endothelial cells(HUVECs) treated with adriamycin for inducing aging were used for cytotoxicity and senescence-associated beta-galactosidase(SA-β-gal) activity assay.
저자
Hyung-Jun Noh [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Geum-Sook Kim [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Seung-Eun Lee [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Gi-Ho Sung [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Dae-Young Lee [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Je-Hun Choi [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Seung-Yu Kim [ Department of Herbal Crop Research, NIHHS, RDA, Eumsung, 369-873, Korea ]
Jae-Ryong Kim [ College of medicine, Yeungnam University, Daegu 705-717, Korea ]
