Earticle

초록

영어

The acute toxicity of a crude extract of maitake mushroom(Grifola frondosa practical compound: GFPC) and the mixture of maitake mushroom extract and white jelly mushroom extract(Tremella fuciformis practical compound: TFPC). For acute oral toxicity test, male and female ICR mice were randomly assigned to five groups, consisting of 12 animals each, six males and six females, received either GFPC or the mixture of GFPC and TFPC, at dose of 0, 2,000 and 5,000mg/kg b.w. by orally(10ml/kg b.w.). For the period of 48hr, clinical signs, body weight and food intake were measured. All animals survived during the study and did not show any clinical signs. Food intake was mildly decreased in both GFPC and the mixture of GFPC and TFPC treated groups, however, body weight gain showed no significant difference among the groups. It is suggested that LD50 of GFPC and the mixture of GFPC and TFPC by oral administration was estimated to be over 5,000mg/kg in both sexes of mice. These results conform that GFPC and the mixture of GFPC and TFPC are safe and no toxic at average dietary level.

목차

ABSTRACT
 서론
 재료 및 방법
  잎새버섯 열수추출물의 제조
  잎새버섯 및 흰목이 버섯 추출 혼합물 제조
  안전성 시험(safety test)
  투여량 설정 및 시험물질 투여
  관찰 항목
 결과 및 고찰
  안전성 시험
 적요
 참고문헌

저자

• 오영주 [ Young-Joo Oh | 풀무원 식문화연구원 기능성연구소 ]
• 박금주 [ Kum-Ju Park | 풀무원 식문화연구원 기능성연구소 ]
• 하효철 [ Hyo-Cheol Ha | 풀무원 식문화연구원 기능성연구소 ]
• 김현수 [ Hyun-Su Kim | 한국국제대학교 제약공학과 ] Corresponding author

참고문헌