This study was carried out to obtain new anti-gout agent from mushrooms. Various extracts from twelve kinds of mushrooms were prepared by water and ethanol extractions and its anti-gout xanthine oxidase inhibitory activity were investigated. Water extract of Flammulina velutipes and Agaricus bisporus fruiting bodies showed high xanthine oxidase inhibitory activity of 70.8% and 60.0%, respectively. However, its inhibitory activity of these ethanol extracts were very low excepet 60.3% of Innotus obliquus. Finally, we selected Flammulina velutipes, showing the highest xanthine oxidase inhibitory activity as a producer of new anti-gout agent.
저자
Jung-Hwa Song [ Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea ]
Bolormaa Zanabaatar [ Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea ]
Jeong-Hoon Jang [ Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea ]
Hyung-Jun Noh [ National Institute of Agricultural Science and Technology, Suwon 441-707, Korea ]
Young-Bok Yoo [ National Institute of Agricultural Science and Technology, Suwon 441-707, Korea ]
Jong-Soo Lee [ Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea ]
Corresponding author
