This study was carried out to investigate neuronal protective activity of fruiting body of Hericium erinaceum. In order to search the effective active compound against amyloid beta peptide-induced oxidative stress on neuronal cells, rat pheochromocytoma cells (PC12), Extracts of Hericium erinaceum were screened and evaluated using both the 2’,7’-dichlorofluorescin diacetate assay (DCF-DA), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. According to above assays, Solvent partitions of extracts were selected for further purification and isolation of anti-Alzheimer’s disease compound as it exerted the highest protective effects against hydrogen peroxide (H2O2)-induced oxidative stress.
저자
Hyung-Jun Noh [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Kang-Hyo Lee [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Chang-Sung Jhune [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Jae-Han Cho [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Gi-Ho Sung [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Kab-Yeul Jang [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Sun-Young Um [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Geum-Soog Kim [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Seung-Eun Lee [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
Young-Ok Kim [ Development of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumseong, Chungbuk, 369-873 ]
