Earticle

초록

영어

A hot water extract(HWE-P4) was separated from the fruit bodies of PMO-P4, and its antitumor and immunomodulatory activities against sarcoma-180 in ICR mice were investigated. The internal transcribed spacer (ITS) regions from PMO-P4 were amplified using polymerase chain reaction(PCR) and sequenced. The results revealed that PMO-P4 was belong to the Phellinus baumii. When oral administration at the dose of 160mg/kg/day in the mice until the end of the experiment with 2 week's pre-feeding of the HWE-P4, the survival rate of the mice was 152% for 50days after the inoculation of sarcoma-180 and the suppression rate of the tumor growth was 35.3%(p<0.05) for 28 days after inoculation of sarcoma-180. The HWE-P4 increased 71.4% of the CD4/CD8 ratio and 5-fold of the expression of CD25(IL- 2 receptor chain) compared with the control. From these results, the antitumor activity of HWE-P4 is exerted through its immunomodulating activity on the host's immune system.

목차

ABSTRACT
 재료 및 방법
  시료준비
  염기서열을 이용한 유연관계 분석
  실험동물
  암세포주
  시료투여
  Sarcoma-180 복수암에 대한 항암 효과 측정
  Sarcoma-180 고형암에 대한 항암 효과 측정
  FACS analysis
  통계학적 처리
 결과 및 고찰
  ITs 영역의 염기서열을 이용한 진흑버섯속균의 유연관계
  Sarcoma-180 복수암에 대한 항암효과
  Sarcoma-180 고형암에 대한 항암효과
  CD4/CD8 증가효과
  CD25 증가효과
  적요
 참고문헌

저자

• 하효철 [ Hyo-Cheol, Ha | 풀무원 식문화 연구원 ] Corresponding author
• 김현표 [ Hyun-Pyo, Kim | 풀무원 식문화 연구원 ]
• 심지영 [ Ji Young, Sim | 풀무원 식문화 연구원 ]
• 장윤희 [ Yun-Hee, Chang | 풀무원 식문화 연구원 ]
• 김현수 [ Hyun Su, Kim | 풀무원 식문화 연구원 ]

참고문헌