Earticle

초록

영어

Transgenic pigs are promising donor organisms for xenotransplantation as they share many anatomical and physiological characteristics with humans. Recently, a step has been moved closer to xenotransplantation by producing genetically modified pigs that has no α-1,3-Gal epitope, the major xenoantigens triggering HAR of pig to primate xenografts. Further genetic modifications such as expression of human complementary regulatory proteins, CD39, endothelial protein C receptor, heme-oxygenase 1, thrombomodulin, tissue factor pathway inhibitoras well as modulators of the HLA-E/β-2-microglobulin, and CTLA-4Ig are due to address for further rejection mechanisms and incompatibilities between porcine and primate blood coagulation systems. Although the pig is the favored species for use as a xenograft donor, a detailed description of the transgenic pig development and surgical technique is lacking which seems mandatory to address for broader understanding of this issue.

목차

ABSTRACT
 INTRODUCTION
 MAJOR OBSTACLES IN XENOTRANSPLANTATION
  Immunological
  Microbiological
 TRANSGENIC TECHNOLOGY AND HISTORICAL PERSPECTIVE
 SUS SCROFAGENOME MODIFICATION
 CONSIDERATIONS FOR ANIMAL MODELS FOR HEART TRANSPLANTATION
 SURGICAL CONSIDERATIONS
 FUTURE DIRECTIONS
 CONCLUSION
 REFERENCES

저자

• 수프리야 시와니 [ Supriya Shiwani | 강원대학교 의생명공학과 ]
• 왕명현 [ Myeong Hyeon Wang | 강원대학교 의생명공학과 ]
• 나레시 쿠마 싱 [ Naresh Kumar Singh | 강원대학교 동물생명공학과 ] Corresponding author

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