Earticle

초록

영어

This study aims to identify DNA marker related to health index which is derived from fatty acid composition of Hanwoo meat. We investigated a genetic association between two SNPs (-867G>C and 878C>T) of SCD gene and health indexes. Two health index values (index of atherogenicity and index of thrombogenicity) were derived from a combination of fatty acid composition. Phenotypic correlation indicated that oleic acid (C18:1) was negatively correlated to index of atherogenicity (-0.84) and index of thrombogenicity (-0.91), respectively. Statistical analysis revealed that 878T>C SNP was significantly associated with IA (index of atherogenicity, p=0.012) and IT (index of thrombogenicity, p=0.006). There was no association between the regulatory SNPs (-867G>C and -877Gdel) and health indexes. Haplotype analysis detected 4 main haplotype (GdelT; 0.004, GdelC; 0.344, CGT; 0.350 and CGC; 0.261) in Hanwoo. The GdelT haplotype was significant on IA and IT. The effect of GdelT haplotype showed increasing IA and IT values, while GdelC haplotype has a decreasing IA and IT value in Hanwoo. In conclusion, the 878C>T SNP in the SCD gene seems to have an effect on this health index and might be implemented into animal breeding program.

목차

ABSTRACT
 I. 서론
 II. 재료 및 방법
  1. 공시재료
  2. 지방산조성
  3. SNP검출 및 유전자형 결정
  4. Haplotype 구성
  5. 동맥경화 및 혈전형성 지수식 도출
  6. 통계분석
 III. 결과 및 고찰
  1. 지방산조성에 따른 표현형 상관관계
  2. SCD유전자  변이(SNP)와 혈전형성 및 동맥경화지수간의 연관성 분석
  3. SCD유전자 변이 일배체형 효과
 IV. 요약
 V. 인용문헌

저자

• 이승환 [ Seung Hwan Lee | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 조용민 [ Yong Min Cho | 농촌진흥청 기획조정관 녹색미래전략팀 ]
• 임다정 [ Da Jung Lim | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 이현정 [ Hyun Jeong Lee | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 최봉환 [ Bong Hwan Choi | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 장길원 [ Gul Won Jang | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 이경태 [ Kyung Tae Lee | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 김남국 [ Nam Kuk Kim | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 허강녕 [ Kang Nyeong Heo | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 오성종 [ Sung Jong Oh | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 김태헌 [ Tae Hun Kim | 농촌진흥청 국립축산과학원 동물유전체과 ]
• 윤두학 [ Duhak Yoon | 농촌진흥청 국립축산과학원 동물유전체과 ] Corresponding Author

참고문헌