Earticle

초록

영어

The purpose of this study was to determined the effect of endurance treadmill running exercise on expression of AMPK and MAPK in aging rat muscle. Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 12wk; n=16) or aging group(AG; 80wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of endurance runing exercise (12m/min for 60min). The expression of phospho-AMPK by endurance exercise was significantly increased in the YG & AG. The ERK 1/2(p<.001) and p38 mitogen-activated protein kinase (MAPK)(p<.05) phosphorylation by bout endurance exercise significantly incresed in YG but decreased in AG. These results suggested that aging was significantly decreased the expression of MAP Kinase by acute endurance treadmill exercise. In conclusion the acute endurance exercise is effective in YG than AG.

목차

Ⅰ. 서론
 Ⅱ. 연구방법
  1. 실험동물 및 처치
  2. 운동 방법
  3. 조직표본 및 분석 방법
  4. 자료처리
 Ⅲ. 결과
  1. 노화와 지구성 운동에 따른 근육 내 AMPK 발현
  2. 노화와 일회 지구성 운동에 따른 근육내 p-ERK 1/2 발현
  3. 노화와 일회 지구성 운동에 따른 근육내 p-p38 MAPK 발현
 Ⅳ. 논의
 Ⅴ. 결론
 참고문헌
 ABSTRACT

저자

• 권중호 [ Kwon, Jung-Ho | 여주대학교 ]
• 어수주 [ Eo, Su-Ju | 한국체육대학교 ]

참고문헌