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Effects of Human Embryonic Stem Cell Transplantation withSingle or Colony Form on the Functional Recovery inSpinal Cord Injured Rats

첫 페이지 보기
  • 발행기관
    응용미약에너지학회 바로가기
  • 간행물
    응용미약자기에너지학회지 바로가기
  • 통권
    Vol.2 No.1 (2004.12)바로가기
  • 페이지
    pp.18-24
  • 저자
    Kye-Seong Kim, Je Kyung Seong, Eun Joo Kim, Un Jeng Kim, Se Jung Jung, Bae Hwan Lee
  • 언어
    한국어(KOR)
  • URL
    https://www.earticle.net/Article/A101393

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원문정보

초록

영어
Embryonic stem (ES) cells derived from the inner cell mass of blastocyst-stage embryos are totipotent.Recent studies indicated the potential use of ES cells on transplantation in the central nervous system with different typeof injuries. The present study was conducted to investigate functional recovery following transplantation of human EScells with single or colony form after SCI. Male Sprague-Dawley rats were anesthetized with sodium pentobarbital andsubjected to SCI model. Rats were laminectomized and SCI was induced using NYU spinal impactor at T9 spinal seg-ment. Human ES (HES) cells with single or colony form were transplanted 1 week after SCI. A behavioral test usingBBB locomotor rating scaling was performed. HES cells transplanted into rats promoted the hindlimb performance, anHES cell transplant significantly improves locomotion recovery. Especially, 2×104 HES cells with single form greatlyimproved hindlimb performance but colony-form did not. Histologically, 2×104 HES cells tended to fill the cavity butsingle form showed more reduced cavity size compared to colony. These results suggest that HES cells with single formare more effective in function recovery after transplantation in spinal cord injured rats compared to colony form.

목차

Abstract
 1. Introduction
 2. Materials and Methods
  2.1. Subjects and spinal cord injury
  2.2. Behavioral assessment after SCI
  2.3. Culture of HES cells
  2.4. Transplantation of HES cells
  2.5. Histological examination
 3. Results
  3.1. Behavioral assessment
  3.2. Histological examination
 4. Discussion
 Acknowledgement
 References

키워드

Spinal cord injury embryonic stem cell transplantation functional recovery

저자

  • Kye-Seong Kim [ Dept. of Anatomy and Cell Biology, Hanyang University, College of Medicine, Seoul 133-791 ]
  • Je Kyung Seong [ Lab. of Developmental Biology and Genomics, Dept. of Anatomy and Cell Biology,College of Veterinary Medicine, Seoul Natl University, Seoul 151-742 ]
  • Eun Joo Kim [ Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science,Yonsei University College of Medicine, Seoul 120-752, Republic of Korea ]
  • Un Jeng Kim [ Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science,Yonsei University College of Medicine, Seoul 120-752, Republic of Korea ]
  • Se Jung Jung [ Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science,Yonsei University College of Medicine, Seoul 120-752, Republic of Korea ]
  • Bae Hwan Lee [ Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science,Yonsei University College of Medicine, Seoul 120-752, Republic of Korea ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    응용미약에너지학회 [The Society of Applied Micromagnetic Energy]
  • 설립연도
    1996
  • 분야
    공학>의공학
  • 소개
    미약자기에너지 및 그 응용에 관한 이론과 기술의 발전 및 보급에 기여함으로써 과학기술의 진흥에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    응용미약자기에너지학회지 [Journal of Applied Micromagnetic Energy]
  • 간기
    반년간
  • pISSN
    1738-4427
  • 수록기간
    2003~2018
  • 십진분류
    KDC 428 DDC 538

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